In European sea bass like in other animals, the tongue plays a fundamental role in the mechanics of food ingestion. It is composed from the surface in depth of mucosa, submucosa, musculature and fibro cartilaginous skeleton. The tunica mucosa exhibits a stratified epithelium interrupted by numerous teeth differently distributed that erupt more or less completely from the layers below. The European sea bass tongue is composed of canine-like teeth, surrounded by taste buds and numerous fungiform and conical papillae. The tongue beeing directly in contact with external environment, the success of the adaptation of fishes to different environments in the context of global change, depends oamong other on the modifications occurring on the tongue structures. The present study investigates the potential effect of ocean acidification on the lingual transcriptome.